Endocrine Abstracts

Objective: The aim of our study was to evaluate the possibility of maintaining the metabolic effects of liraglutide 3.0 mg treatment after it’s cessation.Methods: The study included 8 patients with type 2 diabetes (T2D) and obesity who received liraglutide 3.0 mg daily for 9 months. All of them successfully reduced body weight, insulin resistance level (IR), volume of visceral adipose tissue, HbA1c level. After discontinuation of liraglutide in 2019...

Introduction: Obesity and diabetes mellitus type 2 (T2DM) are considered as one of the major risk factor for coronary heart disease (CHD) development, but the mechanisms beyond this relationship still need to be clarified. miRNAs are supposed to be involved in regulatory mechanisms in this relationship.Aim: To determine miRNAs expression in patients with obesity and T2DM.Methods: MiRNAs were detected in peripheral blood of 43 patie...

Aim of the study: To analyze the dynamics and levels of incretins and neuropeptides secretion in patients with CD and acromegaly and therefore to specify the pathogenesis of carbohydrate metabolism disturbances.Methods: Forty-two patients with Cushing disease and acromegaly were included into the study. All patients were newly diagnosed with Cushing disease and acromegaly. Oral glucose tolerance test (OGTT), during which glucose, glucagon, glucagon like ...